In Vivo

In Vivo

The humanized FRG KO model allows delivery optimization of payloads.  In the example below, humanized FRG KO mice were transduced with 2 X 1011 or 8 X 1011 genome copies of a recombinant AAV-LK03:eGFP. At 13 days post-transduction the livers were isolated and three...
Ex Vivo

Ex Vivo

Primary human hepatocytes, freshly isolated from Yecuris FRGN mice, were transduced with recombinant lentiviruses. A GFP marker revealed transduction efficiencies of >80%. In addition, human hepatocytes were first transduced ex vivo with an NIS (the sodium-iodide...