Yecuris Custom Services
Infectious Disease Studies
No facilities? No problem. Through our partner CRO’s, you can use the FRG® KO mouse model technology to complete infectious disease studies to your specifications.
Ex Vivo Editing → In Vivo Model Generation
Identifying donors with highly specific mutations can be highly challenging, particularly in the case of rare mutations. An alternative approach to cell sourcing is to complete Ex Vivo editing of primary hepatocytes followed by subsequent transplantation of the edited cells into FRG® KO mice to create an In Vivo model of the disease. This model can then be utilized in combination with a therapeutic gene editing technology to reverse the engineered mutation in primary cells.