ACCURATE. RELEVANT. HUMAN.

Liver Humanized Mice and CRO Services

At Yecuris, we believe

• Preclinical research should be as predictive as possible, allowing drug
developers to gain critical insights, proceed into the clinic with certainty, and
have the confidence to make tough go/no go decisions

• The unique ability to use the same donor cells in vivo and in vitro bridge the preclinical pathway to the clinic, giving our clients the greatest predictive data possible

• Our singular goal is to deliver actionable results our clients can depend on,
bringing human relevance to the earliest stages of the drug development
process.

Key Applications for FRG Liver Humanized Mice

Regenerative Medicine

Evaluate cell replacement modalities for cell therapy and iPSCs

Gene & Cell Therapy

Optimization of gene editing technologies and efficacy against genetic diseases

 

Infectious Disease

Model infection of human-specific hepatotropic agents, like malaria and HBV

Metabolic Disorders

Modeling of metabolic disorders like MASH, lipid dysregulation and atherosclerosis

DMPK and Toxicology

Small molecule metabolism, pharmaco-kinetics and safety

What's New at Yecuris?

Events

HBV 2026

We can't wait to head to Singapore September 6th-10th for the International HBV meeting

 

 

 

ASGCT 2026

We're looking forward to attending ASGCT this year from May 10th-15th in Boston

Case Studies

Hemophilia B model in FRG mice

FRG mice repopulated with hepatocytes from a donor with hemophilia B demonstrate clotting deficiency

 

Gene Editor suppressed HBV infection in an AAV-HBV Model

 

New publication of data from a client study performed by Yecuris Research Services. 

News

New Publication

Cholesterol reduction in HFD-fed FRG mice using novel MicroRNA 30c analog C2 - Preprint

New Reagent Release

Yecuris has recently launched a HepaCur Humanized Liver Dissociation Kit for perfusing and digesting humanized FRG livers using commercial dissociation machines.

Thanks again for the successful study. It was great working with you, and I appreciate all the work that you and your team did to help us throughout the study.

Senior Director at a Biotechnology Start Up