PRODUCTS
FRG® Mouse Models
The relevance of data from human tissue generated from an in vivo rodent model
Highly humanized liver with durable engraftment
Genetically stable and reversion-free
Shipping worldwide from our facility in Portland Oregon
Repopulated by any donor
Let our team run your study for you
FRG® Mouse Models:
FRG Liver Humanized Mice
The FRG on C57Bl/6 background was originally reported by Azuma et. al. in 2007. Since then, it has become a staple model for liver humanization and is well suited for studies across many application areas. Engraftment is sustained over the life of the animal with an appropriate regimen of CuRxTM reagents, though in many circumstances, no drug treatment is required.
Livers of FRG mice are >70% repopulated with human hepatocytes. These pathogen-free animals are available as repopulated models with off-the-shelf availability, customizable with your own donor hepatocytes or select from our custom donor library for cells with unique genetic profiles.
Animals are robust for shipment around the world from our USA-based lab to your vivarium or contract research organization. We can also enroll mice into a study at our facility and perform your project for you with our expert CRO Services team.
FRG Non-repopulated Mice
Non-repopulated base-strain FRG mice are available for use in metabolic disease studies, like Type 1 tyrosinemia, or for evaluation of cell therapies for liver transplants. These mice can be withdrawn from Nitisinone to induce selectable liver disease to facilitate these studies or to model cell replacement therapeutic approaches, like with iPSCs or engineered hepatocytes.
These non-repopulated mice are housed and shipped from our barrier facility in Portland, Oregon.