The Perfect Combination

Custom Model Generation

Yecuris offers liver humanized mouse models with custom donors. FRG mice can be transplanted with cells from any donor or species to yield a liver repopulated mouse model suited specifically to your project’s needs. Whether you have been working with a hepatocyte donor in vitro and want in vivo data, have identified a unique genotype, would like to try a non-human species or want to work with our library of defined donors, the FRG platform is the only solution in the market today.

We can produce mice that are shippable to your facility, or we can enroll them directly in a study with our Research Services Team.

HepFinity™ Human Hepatocyte Expansion Services

Do you have a hepatocyte donor that is working well in vitro for your application and want to ensure continuity of the donor across all future experiments? FRG mice can be used as a bioreactor to expand your hepatocytes. Having Yecuris transplant mice with your primary human hepatocytes allows the hepatocytes to proliferate within the in vivo liver. Once humanized, Yecuris can perfuse the livers to isolate expanded numbers of your hepatocytes, giving you a 100X hepatocyte expansion.

Your custom HepaCur Human Hepatocytes can then be cryopreserved into ready- to-thaw vials and shipped back to your facility to extend the available lot size or used in an in vitro study performed at Yecuris.