APPLICATION — NASH & NAFLD
Next-Generation Tools for NASH Research & Discovery
Move beyond chemically-induced steatosis & fibrosis
Humanized FRG KO Models of NASH & NAFLD
2020 Keystone Symposia NAFLD Poster: FRGN PNPLA3 NASH Models
The Real-World, High-Fat Diet Difference
Yecuris Custom Services
Diet-induced humanized mouse models of NAFLD/NASH
FRG-NASH Animals are available as murinized or humanized FRG KO mice, which can be repopulated with our in-house hepatocyte donors or reconstituted as a custom with your donor of choice. Fully reconstituted animals are progressed through the various stages of NASH using our custom high fat diet for FRG KO models. Interventions are determined by the client, depending on whether their approach is prophylactic or therapeutic.
Metabolic Study Monitoring
Assessment of progression of disease states through the monitoring of body weight, food consumption, cholesterol, glucose, insulin and insulin levels.
Prophylactic or Therapeutic assessment of compounds in murinized and humanized FRG KO mice
Custom Hepatocyte Transplantation
Yecuris offers custom hepatocyte transplantation with any donor that you require, from any species. In addition, Yecuris has a selection of NASH genotypic donors including PNPLA3 mutants for specific human relevance. Click here to learn more.
Cell Isolation & Purification
Looking to use cells isolated from FRG® KO mice for your next In Vitro study? Yecuris models act as bioreactors for hepatocytes with geometric expansion up to 100-fold. We have developed processes for optimal isolation of the propagated hepatocytes with subsequent negative bead-based purification to remove residual mouse cells. Our process yields cell products that are over 98% pure with the ability to be shipped in suspension, plated as fresh, or cryopreserved for future work.