Thanks for visiting while attending The Liver Meeting Digital Experience™ 2020 FRG® Liver-Humanized Mice for Translational Studies Products & Services FRG® Mouse Models Highly repopulated humanized mice shipped directly to your vivarium with full tech support. Custom transplants with any FAH+/+ donor Research Services at Yecuris Highly collaborative approach – we are an extension of your lab. Direct channel to our scientists & dedicated customer support HepaCur Human Hepatocytes Same donor expanded & isolated from humanized mice then delivered directly to your lab. Available fresh or cyropreserved HepaCur Reagent Portfolio All of our reagents are made in the USA and validated internally with our FRG® colony prior to client use. Learn about how liver-humanized FRG® mice are used by researchers across the globe. Gene Therapy & Gene Editing Mainly liver-targeted gene therapies AAV, Lenti, LNP, Crispr RNP Off-target effects shRNA screens Antisense oligonucleotide tx Rare metabolic & genetic diseases Cross-species comparisons (mouse, monkey, human, etc.) Infectious Diseases Gold standard for testing of hepato-tropic pathogens Viral Hepatitis (HBV & HCV, mainly) Malaria Yellow fever First humanized mice to be challenged with SARS-COV2 We work with outside CROs for infectious diseases NASH & NAFLD Tool for studying NASH disease progression Diet induced, no chemical induction More representative of a natural, human disease response CVD relevance Human lipid profiles Hypercholesterolemia Atherosclerosis DMPK & Toxicology Human liver-mediated metabolism & excretion of drugs and xenobiotics Drug-drug interactions Short- & long-term investigation of the toxicity of drugs or chemicals with significant human exposure TALK TO OUR SCIENTISTS The Liver Meeting Digital Experience™ is a registered trademark of the American Association for the Study of Liver Diseases.