Validate Your Approach with Human Relevance.
A complete platform from in vitro development & optimization to in vivo validation
Uses of FRG® KO Models in Gene Editing Applications
Gene editing technologies have evolved rapidly over the last decade, yet drug developers are struggling to advance programs to market. Designing gene delivery vehicles using traditional rodent models translates poorly to the clinic because these models lack human relevance. Liver-humanized FRG® KO animal models provide a new toolset for researchers in this space by allowing optimization, verification of target specificity, and evaluation of off-target effects in a human relevant setting. When speed and accuracy are critical to your program’s success, Yecuris in vitro and in vivo technologies are there to bridge the gap between bench and clinic.
Correction of humanized OTC FRG® KO Mouse model using ex vivo gene editing of human hepatocytes
FRG® KO Platform Advantage is a complete system to:
- Screen & optimize your delivery vehicle and/or payload in vitro using HepaCur™ freshly isolated or cryopreserved human hepatocytes
- Validate your leads in vivo with liver-humanized FRG® KO mouse models
- Use our custom transplant service to create animals with hepatocytes of your choice:
- any species (human, non-human primate, pig, rat, etc.)
- any genotypically defined donor (PNPLA3, GSD, OTC, MSUD, etc.)
- any donor of your choice

Target — are you hitting your specific target?

Payload — is your construct delivered?

Function — is your approach working?
with precision.