Next-Generation tools for hepatic research and discovery.
Why Did You Come Here?
How We Can Help
Key Applications for FRG® KO Mice
Gene & Cell Therapy
Optimization and efficacy scoring of gene editing technologies
Infection of models by human specific hepatotropic agents for mechanistic and efficacy testing
Compound assessment of human NASH and NAFLD in humanized FRG® KO models on high fat diet
A True Human Liver Model
FRG: the complete platform from in vitro development & optimization to in vivo validation.
The key advantages of human hepatocytes cultured in FRG® KO animals versus traditionally-supplied cells:
Consistent Cell Quality—Our controlled process yields fresh cells with consistency and quality unmatched from human cadaver derived products.
Consistent Cell Availability—Unlike typical fresh cells from cadavers that are only available to you once, HepaCur™ Fresh human hepatocytes are available throughout your discovery process.
Plannable Fresh—Since cells are isolated on demand for you, fresh cells from our qualified donors can be isolated on a weekly schedule. No more waiting lists or 3 a.m. calls.
Long Lasting—Cells demonstrate superior morphology for periods greater than twelve days without feeder cells or gel overlay.
Normal Activity—Activity levels of metabolizing enzymes are normal as compared to traditionally acquired materials.
Premium human hepatocytes available for delivery every week, plated or in suspension.
Yecuris FRG Platform
Humanized Animal Models