AASLD 2020

Thanks for visiting from The Liver Meeting 2020!

FRG® Liver-Humanized Mice for Preclinical Studies

Learn about how liver-humanized FRG® mice are used by researchers across the globe.

Gene Therapy & Gene Editing

  • Mainly liver-targeted gene therapies
  • AAV, Lenti, LNP, Crispr RNP
  • Off-target effects
  • shRNA screens
  • Antisense oligonucleotide tx
  • Rare metabolic & genetic diseases
  • Cross-species comparisons (mouse, monkey, human, etc.)

Infectious Diseases

  • Gold standard for testing of hepato-tropic pathogens
  • Viral Hepatitis (HBV & HCV, mainly)
  • Malaria
  • Yellow fever
  • First humanized mice to be challenged with SARS-COV2
  • We work with outside CROs for infectious diseases

NASH & NFLD

  • Tool for studying NASH disease progression
  • Diet induced, no chemical induction
  • More representative of a natural, human disease response
  • CVD relevance
  • Human lipid profiles
  • Hypercholesterolemia
  • Atherosclerosis

DMPK & Toxicology

  • Human liver-mediated metabolism & excretion of drugs and xenobiotics
  • Drug-drug interactions
  • Short- & long-term investigation of the toxicity of drugs or chemicals with significant human exposure
Products & Services

FRG® Mouse Models

Highly repopulated humanized mice shipped directly to your vivarium with full tech support. Custom transplants with any FAH+/+ donor

Research Services at Yecuris

Highly collaborative approach – we are an extension of your lab. Direct channel to our scientists & dedicated customer support

HepaCur Human Hepatocytes

Same donor expanded & isolated from humanized mice then delivered directly to your lab. Available fresh or cyropreserved

HepaCur Reagent Portfolio

All of our reagents are made in the USA and validated internally with our FRG® colony prior to client use.