Background

  1. Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice. – Foquet L, Wilson EM, Verhoye L, Grompe M, Leroux-Roels G, Bial J, Meuleman P. Methods Mol Biol. 2017;1506:117-130
  2. Functional Integrity of Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters. – Chow EC, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS. Drug Metab Dispos. 2016 Sep;44(9):1524-35.
  3. Extensive double humanization of both liver and hematopoiesis in FRGN mice. – Wilson EM, Bial J, Tarlow B, Bial G, Jensen B, Greiner DL, Brehm MA, Grompe M. Stem Cell Res. 2014 Nov;13(3 Pt A):404-12.
  4. Fibroblast Growth Factor Signaling Controls Liver Size in Mice with Humanized Livers. – Naugler WE, Tarlow BD, Fedorov LM, Taylor M, Pelz C, Li B, Darnell J, Grompe M. Gastroenterology. 2015 Sep;149(3):728-40.
  5. Mouse liver repopulation with hepatocytes generated from human fibroblasts. – Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Nature. 2014 Apr 3;508(7494):93-7.
  6. Mice with human livers. – Grompe M, Strom SC.  Gastroenterology. 2013 Dec;145(6):1209-14
  7. Response to “Can ‘humanized’ mice improve drug development in the 21st century?” – Bissig KD, Grompe M. Trends Pharmacol Sci. 2013 Aug;34(8):425
  8. New potential cell source for hepatocyte transplantation: discard livers from metabolic disease liver transplants. – Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, Venkataramanan R, Ellis EC, Jorns C, Ericzon BG, Rosenborg S, Kuiper R, Soltys KA, Mazariegos GV, Fox IJ, Wilson EM, Grompe M, Strom SC. Stem Cell Res. 2013 Jul;11(1):563-73
  9. Xeno-repopulation of Fah-/- Nod/Scid mice livers by human hepatocytes. – Su B, Liu C, Xiang D, Zhang H, Yuan S, Wang M, Chen F, Zhu H, He Z, Wang X, Hu Y.  Sci China Life Sci. 2011 Jun;54(3):227-34
  10. Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. – Strom SC, Davila J, Grompe M. Methods Mol Biol. 2010;640:491-509
  11. Therapeutic liver reconstitution with murine cells isolated long after death. – Erker L, Azuma H, Lee AY, Guo C, Orloff S, Eaton L, Benedetti E, Jensen B, Finegold M, Willenbring H, Grompe M. Gastroenterology. 2010 Sep;139(3):1019-29
  12. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. – Bissig KD, Le TT, Woods NB, Verma IM. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20507-11
  13. Robust expansion of human hepatocytes in Fah-/- / Rag2-/- / Il2rg-/- mice. – Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. Nat Biotechnol. 2007 Aug;25(8):903-10

Metabolism

  1. The pharmacokinetics and metabolism of lumiracoxib in chimeric humanized and murinized FRG mice. – Dickie AP, Wilson CE, Schreiter K, Wehr R, Wilson EM, Bial J, Scheer N, Wilson ID, Riley RJ. Biochem Pharmacol. 2017 Jul 1;135-150
  2. Mice with chimeric liver are an improved model for human lipoprotein metabolism – Ellis EC, Nauglers S, Parini P, Mörk LM, Jorns C, Zemack H, Sandblom AL, Björkhem I, Ericzon BG, Wilson EM, Strom SC, Grompe M. PLoS One. 2013 Nov 4;8(11)
  3. View our poster as presented at the 2012 JSSX meeting in Tokyo:  Investigation of Hepatic Clearance and Metabolism of Drugs in Chimeric FRG® KO Mice with Humanized Liver.
  4. View our poster as presented at the 2012 ESSX-MDO meeting in Noordwijk aan Zee: Investigation of Hepatic Clearance of Drugs in Chimeric Mice with Humanized Liver.
  5. View our poster as presented at the 2012 AFSTAL meeting in Marseille: Investigation of Hepatic Clearance of Drugs in Chimeric Mice with Humanized Liver.
  6. View our poster as presented at the 2009 ISSX meeting in Baltimore: In Vitro Inhibition and Induction of Human Cytochrome P450 Enzymes by NTBC and its Metabolism in Human Liver Microsomes.

Infectious Disease

  1. Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma. – Sayed IM, Foquet L, Verhoye L, Abravanel F, Farhoudi A, Leroux-Roels G, Izopet J, Meuleman P. Antiviral Res. 2017 Feb 21;141:150-154
  2. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. – Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Carke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusocsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL. Nature. 2016 Oct 20;538(7625):344-349
  3. Combinitorial RNA interference therapy prevents selection of pre-existing HBV variants in human liver chimeric mice. – Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH. Sci Rep. 2015 Oct;5:15259
  4. Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model. Calattini S, Fusil F, Mancip J, Dao Thi VL, Granier C, Gadot N, Scoazec JY, Zeisel MB, Baumert TF, Lavillette D, Dreux M, Cosset FL. J Biol Chem. 2015 Sep 18;290(38):23173-87.
  5. Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. – Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, Kappe SH. Cell Host Microb. 2015 Apr 8;17(4):526-35
  6. View our poster as presented at the 2013 ICAR meeting in San Francisco: FRG® KO mice with humanized livers as a robust model for HBV drug discovery.
  7. Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. – Vaughan AM, Mikolajczak SA, Wilson EM, Grompe M, Kaushansky A, Camargo N, Bial J, Ploss A, Kappe SH. J Clin Invest. 2012 Oct 1;122(10):3618-28
  8. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. – Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, Verma IM. J Clin Invest. 2010 Mar;120(3):924-30

Toxicology

  1. The pharmacokinetics and metabolism of lumiracoxib in chimeric humanized and murinized FRG mice. – Dickie AP, Wilson CE, Schreiter K, Wehr R, Wilson EM, Bial J, Scheer N, Wilson ID, Riley RJ. Biochem Pharmacol. 2017 Jul 1;135-150
  2. Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice. – Samuelsson K, Pickup K, Sarda S, Foster JR, Randall K, Abrahamsson A, Jacobsen M, Weidolf L, Wilson I. Xenobiotica. 2014 Jan;44(2):186-95

In Vitro

  1. Microphysical space of a liver sinusoid decice enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes. -Maher SP, Crouse RB, Conway AJ, Bannister EC, Achyuta AK, Clark AY, Sinatra FL, Cuiffi JD, Adams JH, Kyle DE, Saadi WM. Biomed Microdevices. 2014 Octl 16(5):727-36
  2. Robust expansion of human hepatocytes in Fah-/- / Rag2-/- / Il2rg-/- mice. – Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. Nat Biotechnol. 2007 Aug;25(8):903-10

Gene Therapy

  1. Combinitorial RNA interference therapy prevents selection of pre-existing HBV variants in human liver chimeric mice. – Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH. Sci Rep. 2015 Oct;5:15259
  2. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. – Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Kettlun-Leyton C, Leung HC, Kruse RL, Himes RW, Foss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Nat Commun. 2015 Jun 17;6:7339
  3. Selection and evaluation of clinically relevant AAV variants in a xenograft liver model. – Lisowski L, Dane AP, Chu K, Zhang Y, Cunningham SC, Wilson EM, Nygaard S, Grompe M, Alexander IE, Kay MA. Nature. 2014 Feb 20;506(7488):382-6
  4. Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. – Paulk NK, Wursthorn K, Wang Z, Finegold MJ, Kay MA, Grompe M. Hepatology. 2010 Apr;51(4):1200-8

Stem Cells

  1. A drug screen using human iPSC-derived hepatocyte-like cells reveals cardiac glycosides as a potential treatment for hypercholesterolemia. – Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA. Cell Stem Cell. 2017 Apr 6;20(4):478-489
  2. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. – Tarlow BD, Pelz C, Naugler WE, Wakefield L, Wilson EM, Finegold MJ, Grompe M. Cell Stem Cell. 2014 Nov 6;15(5):605-18

Cancer Biology

  1. Murine model of hepatic breast cancer. – Rikhi RR, Wilson EM, Deas O, Svalina NM, Bial J, Mansoor A, Cairo S, Keller C. BBRC. 2016 Dec;8:1-5
  2. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. – Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Hyuang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, Lopez-Terrada D, Bissig KD. J Hepatol. 2016 Aug;65(2):325-33