FRG® KO Mouse Models:
FRG® KO on C57BI/6
Humanized Liver Models
These mice are available as repopulated models with human liver cells from multiple qualified donors.
We also offer mice repopulated with C57Bl/6 hepatocytes for use as controls, as well as custom transplants to suit your study needs.
FRG® KO on NOD
Liver Modeling with Humanizable Immune Systems
The FRG® KO on NOD was developed to promote the engraftment of both human liver and immune systems. Available as a liver-only chimera or custom-ordered as a liver-immune dual chimera.
If the immune system could be an important part of your research plan, you may benefit from starting with this model.
Key Applications for FRG® KO Mice
Gene & Cell Therapy
Optimization and efficacy scoring of gene editing technologies
Infection of models by human specific hepatotropic agents for mechanistic and efficacy testing
Compound assessment of human NASH and NAFLD in humanized FRG® KO models on high fat diet