Alirocumab Response in FRG Mice
Regulation of Lipoprotein (a) Metabolism by PCSK9 in Animal Models
Villard et. al., 2016
T. T. T. Tran, E. Villard, B. Poirier, E. Guillot, JC. Le Bail, C. Boixel, D. Boulay, J. Blankenstein, A. Parkar, T. Muslin and P. Janiak
Low density liprotein-cholesterol (LDL-C), a major risk factor for coronary heart disease, is a primary interventional target for lipid-lowering PCSK9 antibodies such as Alirocumab. In contrast to statins, Alirocumab also significantly reduces plasma lipoprotein (a) (Lp(a)) in patients, another independent risk factor of cardiovascular diseases including aortic valve stenosis. FRG KO mice and non-human primates are utilized to demonstrate that liver humanized mouse models faithfully recapitulate that Aliorocumab decreased plasma LDL-C and Lp(a) levels.